Endocrine Abstracts

Metformin has been used extensively in multiple reproductive settings including to ameliorate hyperandrogenism and chronic anovulation, to treat infertility, to prevent miscarriage and to prevent later pregnancy complications. Metformin does result in modest improvements in the PCOS phenotype with reductions in circulating insulin and testosterone levels, weight loss, and improved menstrual/ovulatory frequency. It is relatively ineffective as a solo agent to treat infertility,...